In this paper, we propose a novel approach to achieving the goal of preemptive blocking of malicious third-party content inclusion through an analysis of inclusion sequences on the Web. We implemented our approach, called Excision, as a set of modifications to the Chromium browser that protects users from malicious inclusions while web pages load. Our analysis suggests that by adopting our in-browser approach, users can avoid a significant portion of malicious third-party content on the Web. Our evaluation shows that Excision effectively identifies malicious content while introducing a low false positive rate. Our experiments also demonstrate that our approach does not negatively impact a user’s browsing experience when browsing popular websites drawn from the Alexa Top 500.